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Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis
journal contribution
posted on 2023-01-31, 22:23 authored by S Tognin, A Riecher-Rössler, E M Meisenzahl, S J Wood, C Hutton, S J Borgwardt, N Koutsouleris, Alison YungAlison Yung, P Allen, L J Phillips, P D McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A MechelliBackground Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. Method We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical alterations in UHR subjects, using voxel-based cortical thickness. Results At baseline UHR subjects, compared with controls, showed reduced cortical thickness in the right parahippocampal gyrus (p<0.05, familywise error corrected). There were no significant differences in cortical thickness between the UHR subjects who later developed psychosis and those who did not. Conclusions These data suggest that UHR symptomatology is characterized by alterations in the thickness of the medial temporal cortex. We did not find evidence that the later progression to psychosis was linked to additional alterations in cortical thickness, although we cannot exclude the possibility that the study lacked sufficient power to detect such differences. © 2013 Cambridge University Press.
History
Journal
Psychological MedicineVolume
44Pagination
489 - 498Publisher DOI
ISSN
0033-2917eISSN
1469-8978Publication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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Social SciencesScience & TechnologyLife Sciences & BiomedicinePsychology, ClinicalPsychiatryPsychologyCerebral cortexmagnetic resonance imagingparahippocampal gyrusprodromal periodschizophrenic psychosesvoxel-based cortical thickness1ST EPISODE SCHIZOPHRENIAANTERIOR CINGULATE CORTEXVOXEL-BASED MORPHOMETRYNEUROANATOMICAL ABNORMALITIES1ST-EPISODE PSYCHOSISALZHEIMERS-DISEASEMATTER CHANGESMENTAL STATESVOLUMEONSET
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