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Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?

Version 2 2024-06-13, 09:36
Version 1 2016-01-06, 16:38
journal contribution
posted on 2024-06-13, 09:36 authored by C Chen, J Zhou, C Liu, K Witt, Y Zhang, B Jing, C Li, X Wang, L Li
The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.

History

Journal

Journal of neuropsychiatry and clinical neurosciences

Volume

27

Season

Winter

Pagination

27-32

Location

Washington, D.C.

ISSN

0895-0172

eISSN

1545-7222

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2015, American Psychiatric Press

Issue

1

Publisher

American Psychiatric Press

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