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Reinforcing silk scaffolds with silk particles

journal contribution
posted on 10.06.2010, 00:00 authored by Rangam RajkhowaRangam Rajkhowa, E Gil, J Kluge, K Numata, Lijing Wang, Xungai WangXungai Wang, D Kaplan
Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength of HFIP-based scaffolds. This increase in mechanical properties resulted from the high interfacial cohesion between the silk matrix and the reinforcing silk particles, due to partial solubility of the silk particles in HFIP. The porosity of scaffolds was reduced from ≈90% (control) to ≈75% for the HFIP systems containing 200% particle reinforcement, while maintaining pore interconnectivity. The presence of the particles slowed the enzymatic degradation of silk scaffolds.

History

Journal

Macromolecular bioscience

Volume

10

Issue

6

Pagination

599 - 611

Publisher

Wiley Interscience

Location

Weinheim, Germany

ISSN

1616-5187

eISSN

1616-5195

Language

eng

Publication classification

C1 Refereed article in a scholarly journal; C Journal article

Copyright notice

2010, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim