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Reinforcing silk scaffolds with silk particles
journal contribution
posted on 2010-06-10, 00:00 authored by Rangam RajkhowaRangam Rajkhowa, E Gil, J Kluge, K Numata, Lijing Wang, Xungai WangXungai Wang, D KaplanSilk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength of HFIP-based scaffolds. This increase in mechanical properties resulted from the high interfacial cohesion between the silk matrix and the reinforcing silk particles, due to partial solubility of the silk particles in HFIP. The porosity of scaffolds was reduced from ≈90% (control) to ≈75% for the HFIP systems containing 200% particle reinforcement, while maintaining pore interconnectivity. The presence of the particles slowed the enzymatic degradation of silk scaffolds.
History
Journal
Macromolecular bioscienceVolume
10Issue
6Pagination
599 - 611Publisher
Wiley InterscienceLocation
Weinheim, GermanyPublisher DOI
ISSN
1616-5187eISSN
1616-5195Language
engPublication classification
C1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2010, WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimUsage metrics
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Categories
Keywords
biodegradablecompositesparticlesscaffoldssilkScience & TechnologyLife Sciences & BiomedicineTechnologyPhysical SciencesBiochemistry & Molecular BiologyMaterials Science, BiomaterialsPolymer ScienceMaterials ScienceIN-VITRO DEGRADATIONCOMPOSITE SCAFFOLDSPHYSICOCHEMICAL PROPERTIESFIBROIN NANOCOMPOSITEPROTEIN SCAFFOLDSBONE REGENERATION3-D SCAFFOLDS3D SCAFFOLDSSTEM-CELLSTISSUE