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Relationship between adverse childhood experiences and Alzheimer's disease: A systematic review and meta-analysis protocol

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journal contribution
posted on 2024-07-02, 06:30 authored by Kayla CorneyKayla Corney, Julie PascoJulie Pasco, Amanda StuartAmanda Stuart, Emma WestEmma West, Shae QuirkShae Quirk, B Azimi Manavi, Lana WilliamsLana Williams
IntroductionAlzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite this accumulating evidence, current identified factors do not explain the full extent of disease onset. Thus, the role of additional factors needs to be explored further.One such factor is exposure to adverse childhood experiences. However, the degree of this association is unknown. This systematic review will examine the literature investigating the associations between adverse childhood experiences and the risk of Alzheimer’s disease.Methods and analysisArticles investigating associations between exposure to adverse childhood experiences and the risk of Alzheimer’s disease will be identified systematically by searching CINAHL, MEDLINE and PsycInfo using Ebscohost. No restrictions on date of publication will be applied. The search strategy will be built combining the main key elements of the Population, Exposure, Comparator, and Outcomes inclusion criteria. A meta-analysis is planned and statistical methods will be used to identify and control for heterogeneity, if possible. The development of this protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Ethics and disseminationOnly published data will be used for this study, thus, ethical approval will not be required. Findings of the review will be published in a peer-reviewed scientific journal, and presented at national and international conferences.PROSPERO registration numberCRD42020191439.

History

Journal

BMJ Open

Volume

11

Article number

ARTN e049768

Pagination

1 - 5

Location

England

Open access

  • Yes

ISSN

2044-6055

eISSN

2044-6055

Language

eng

Publication classification

C2 Other contribution to refereed journal

Issue

8

Publisher

BMJ PUBLISHING GROUP