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Relationship between serotonin and the temperament and character inventory
journal contribution
posted on 1999-12-13, 00:00 authored by A R Peirson, J W Heuchert, L Thomala, Michael BerkMichael Berk, H Plein, C R CloningerThe unified biosocial theory of personality, proposed by Cloninger, conceptualises personality as a combination of heritable, neurobiologically based traits (temperament dimensions), and traits reflecting sociocultural learning (character dimensions). The temperament dimensions are thought to be related to activity in specific central neurotransmitter systems. The relationship of the dimensions of the Temperament and Character Inventory, particularly harm avoidance (HA), and platelet 5-HT2 receptor sensitivity was investigated in a sample of undergraduate student volunteers (N = 49). Serotonin-receptor binding results in Ca2+ release from intracellular stores. The concentration of serotonin required to produce half maximal Ca2+ response (EC50) is indicative of 5-HT2 receptor sensitivity such that the lower the EC50 serotonin concentration, the greater the 5-HT2 receptor sensitivity. A significant inverse correlation was found between HA and EC50 (r = -0.644, P < 0.001). Self-directedness was also significantly correlated with EC50 (r = 0.391, P = 0.005). Novelty seeking, a personality trait similar to sensation seeking, was not significantly correlated with serotonin.
History
Journal
Psychiatry ResearchVolume
89Issue
1Pagination
29 - 37Publisher
Elsevier IrelandLocation
Shannon, Clare IrelandPublisher DOI
ISSN
0165-1781Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1999, Elsevier Science IrelandUsage metrics
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Categories
Keywords
adultarousalblood plateletsdefense mechanismsfemalehumansmalepersonalityreceptorsreference Valuesserotonintemperament and character inventoryharm avoidanceScience & TechnologyLife Sciences & BiomedicinePsychiatryTRIDIMENSIONAL PERSONALITY QUESTIONNAIRECALCIUM MOBILIZATIONSENSATION SEEKINGPLATELETSDISORDERSMETABOLITESINHIBITORSMODEL