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Reliance on external cues during serial sequential movement in major depression.

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Version 2 2024-06-03, 13:25
Version 1 2015-08-27, 14:12
journal contribution
posted on 2024-06-03, 13:25 authored by Mark RogersMark Rogers, JL Bradshaw, JG Phillips, E Chiu
Maintenance of motor set in patients with unipolar major depression was examined. Twelve melancholic and 12 non-melancholic depressed patients and 24 age matched controls performed a serial choice reaction time task while external cues aiding maintenance of a motor set were systematically removed. Melancholic patients were significantly slower than controls with no reduction in external cues and with a moderate reduction in external cues. At a high level of reduction in external cues, seven of 12 melancholic patients (but only three of 12 non-melancholic patients and controls) were unable to complete the task; suggesting a greater reliance on external cues, perhaps implicating a failure of motor planning ability in melancholic patients. This, in turn, may point to a prefrontal (premotor) deficit in melancholic depression, with possible commonalities with Parkinson's disease.

History

Journal

Journal of neurology, neurosurgery, and psychiatry

Volume

69

Pagination

237-239

Location

England

Open access

  • Yes

ISSN

0022-3050

Language

eng

Publication classification

CN.1 Other journal article

Issue

2

Publisher

BMJ Publishing Group

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