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Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications

journal contribution
posted on 2015-07-01, 00:00 authored by Shilpa Aggarwal, Seetal DoddSeetal Dodd, Michael BerkMichael Berk
Restless leg syndrome (RLS) is a common disorder, frequently of unclear origin, which is often associated with significant distress. There are a few case reports of atypical antipsychotic agents (AAP) causing RLS. The pathophysiological mechanisms resulting in emergence of these movements suggest central dopaminergic dysfunction. Dopamine agonists and L-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Genetic influences are implicated in RLS and an association between gene polymorphisms and antipyschotic-associated onset of RLS has been postulated. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness-related agitation might help in reducing the distress associated with it and improving patient compliance in patients using atypical antipsychotic agents.

History

Journal

Current drug safety

Volume

10

Issue

2

Pagination

98 - 105

Publisher

Bentham Science Publishers

Location

San Francisco, Calif.

ISSN

1574-8863

eISSN

2212-3911

Language

eng

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

2015, Bentham Science Publishers

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