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Restless leg syndrome caused by olanzapine: a case series
journal contribution
posted on 2010-04-01, 00:00 authored by Shilpa Aggarwal, Seetal DoddSeetal Dodd, Michael BerkMichael BerkRestless leg syndrome (RLS) is a common disorder associated with significant distress. We report three cases of drug induced RLS caused by olanzapine. In each case, RLS commenced after initiation of treatment with olanzapine and resolved after ceasing olanzapine. All three patients were subsequently treated with other atypical antipsychotics, risperidone, quetiapine or aripiprazole, without re-emergence of RLS. RLS is associated with central dopaminergic dysfunction. Dopamine agonists and l-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness related agitation might help in reducing the distress associated with it and improving patient compliance.
History
Journal
Current drug safetyVolume
5Issue
2Pagination
129 - 131Publisher
Bentham Science PublishersLocation
San Francisco, Ca.Publisher DOI
ISSN
1574-8863eISSN
2212-3911Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2010, Bentham Science PublishersUsage metrics
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