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Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta‐analysis of randomized controlled trials

journal contribution
posted on 2023-04-03, 05:35 authored by Nazanin Mohammadipoor, Fatemeh Shafiee, Amirabbas Rostami, Mohammad Saeed Kahrizi, Hamidreza Soleimanpour, Majid ghodsi, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Behrooz Jannat, Erfan Mosharkesh, Mohammad Sadegh Pour Abbasi
We perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to quantify the effect of resveratrol supplementation on endothelial function. A comprehensive search was performed in electronic databases including PubMed, Scopus, Web of Science, and Cochrane Library up to February 2021 with no limitation in time and language. A meta-analysis of eligible studies was performed using a random-effects model to estimate the pooled effect size of flow-mediated dilation (FMD), intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1). In total, 21 arms from 17 studies were included. The meta-analysis results showed that resveratrol significantly change the concentrations of FMD (WMD: 1.43%; 95% CI: 0.98 to 1.88, p < .001) and ICAM-1 (WMD: -7.09 ng/ml, 95% CI: -7.45 to -6.73, p < .001). However, VCAM-1, fibrinogen, and PAI-1 did not change significantly after resveratrol supplementation. In conclusion, the results of this study suggest that resveratrol supplementation can improve endothelial function which could be important, especially in patients with cardiovascular diseases.

History

Journal

Phytotherapy Research

Volume

36

Pagination

3529-3539

Location

England

ISSN

0951-418X

eISSN

1099-1573

Language

en

Issue

9

Publisher

Wiley