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Retinal tissue thickness is reduced in diabetic peripheral neuropathy
journal contribution
posted on 2016-01-01, 00:00 authored by S Srinivasan, N Pritchard, D Vagenas, K Edwards, Geoff SampsonGeoff Sampson, A W Russell, R A Malik, N EfronAIM: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness. METHODS: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0-10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels. RESULTS: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04). CONCLUSIONS: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.
History
Journal
Current eye researchVolume
41Issue
10Pagination
1359 - 1366Publisher
Taylor & FrancisLocation
London, Eng.Publisher DOI
eISSN
1460-2202Language
engPublication classification
C1.1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2016, Taylor & FrancisUsage metrics
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Diabetic peripheral neuropathyganglion cell complexneuropathy disability scoreretinal nerve fiber layerretinal thicknessScience & TechnologyLife Sciences & BiomedicineOphthalmologyOPTICAL COHERENCE TOMOGRAPHYNERVE-FIBER DAMAGELAYER THICKNESSMACULAR THICKNESSGLYCEMIC CONTROLRISK-FACTORSSTRATUS OCTRETINOPATHYDISEASECOMPLICATIONS
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