Deakin University
Browse

File(s) under permanent embargo

Retinal tissue thickness is reduced in diabetic peripheral neuropathy

Version 2 2024-06-03, 21:16
Version 1 2016-03-10, 14:31
journal contribution
posted on 2024-06-03, 21:16 authored by S Srinivasan, N Pritchard, D Vagenas, K Edwards, Geoff SampsonGeoff Sampson, AW Russell, RA Malik, N Efron
AIM: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness. METHODS: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0-10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels. RESULTS: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04). CONCLUSIONS: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.

History

Journal

Current eye research

Volume

41

Pagination

1359-1366

Location

London, Eng.

eISSN

1460-2202

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal, C Journal article

Copyright notice

2016, Taylor & Francis

Issue

10

Publisher

Taylor & Francis