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Rhenium and technetium tricarbonyl complexes of 1,4-substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide

Version 2 2024-06-04, 08:06
Version 1 2017-08-04, 10:50
journal contribution
posted on 2024-06-04, 08:06 authored by Tim ConnellTim Connell, David HayneDavid Hayne, U Ackermann, HJ Tochon-Danguy, JM White, PS Donnelly
New 1,4-substituted pyridyl-1,2,3-triazole ligands with pendent phenyl isothiocyanate functional groups linked to the heterocycle through a short methylene or longer polyethylene glycol spacers were prepared and conjugated to a peptide containing the arginine-glycine-aspartic acid peptide motif. Rhenium and technetium carbonyl complexes, [M(CO)3 L(x) (py)](+) (where M = Re(I) or (99m) Tc(I) ; L(x)  = 1,4-substituted pyridyl-1,2,3-triazole ligands and py = pyridine) were prepared. One rhenium complex has been characterized by X-ray crystallography, and the luminescent properties of [M(CO)3 L(x) (py)](+) are reported.

History

Journal

Journal of labelled compounds and radiopharmaceuticals

Volume

57

Season

Special issue: current developments in PET and SPECT imaging

Pagination

262-269

Location

London, Eng.

ISSN

0362-4803

eISSN

1099-1344

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2013, John Wiley & Sons, Ltd.

Issue

4

Publisher

Wiley-Blackwell