Ribosome inactivating proteins (RIPs) from momordica charantia for anti viral therapy
journal contribution
posted on 2009-01-01, 00:00authored byMunish Puri, I Kaur, Rupinder Kanwar, R Gupta, A Chauhan, Jagat Kanwar
This review describes the nature and applications of ribosome inactivating proteins (RIPs) from Momordica charantia (bitter melon). RIPs from the plant kingdom have received much attention in biomedical research because they target conserved host protein synthesis machinery and show specificity towards human and animal cell targets. Recent studies aimed at unravelling the enzymatic activities of the M charantia RIPs provide a structural basis for their activities. It has been reported that RIPs are member of the single chain ribosome inactivating protein (SCRIP) family which act irreversibly on ribosome by removing adenine residue from eukaryotic ribosomal RNA. Various activities of RIPs include anti-tumor, broad anti-viral, ribonuclease and deoxyribonuclease. MAP30 (Momordica Anti-HIV Protein), alpha- and beta-momorcharins inhibit HIV replication in acutely and chronically infected cells and thus are considered potential therapeutic agent in HIV infection and AIDS. Further, MAP30 improved the efficacy of anti-HIV therapy when used in combination with other anti-viral drugs. MAP30 holds therapeutic promise over other RIPs because not only it is active against infection and replication of both HSV and HIV but is non toxic to normal cells. Here we review the nature, action, structure function relationship and applications of RIPs from Momordica charantia and evaluate their potential for anti-cancer and anti-viral therapy.
History
Journal
Current molecular medicine
Volume
9
Issue
9
Pagination
1080 - 1094
Publisher
Bentham Science Publishers
Location
Bussum, Netherlands
ISSN
1566-5240
eISSN
1875-5666
Language
eng
Publication classification
C1 Refereed article in a scholarly journal; C Journal article