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Ring opening polymerization of α-amino acids: Advances in synthesis, architecture and applications of polypeptides and their hybrids
journal contribution
posted on 2020-07-21, 00:00 authored by Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei DuanWei Duan, Neil M O'Brien-Simpson, Greg G QiaoPolypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with rational monomer composition can direct architecture, self-assembly and chemical behavior, ultimately guiding the choice of appropriate application within the biomedical field. This review focuses on the applications of polypeptides alongside the synthetic advances in the ring opening polymerization of α-amino acid N-carboxyanhydrides achieved in the past five years. Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the wide range of applications towards which polypeptides have been applied.
History
Journal
Chemical Society ReviewsVolume
49Issue
14Pagination
4737 - 4834Publisher
Royal Society of ChemistryLocation
Cambridge, Eng.Publisher DOI
ISSN
0306-0012eISSN
1460-4744Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2020, Royal Society of ChemistryUsage metrics
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No categories selectedKeywords
CATIONIC HELICAL POLYPEPTIDESChemistryChemistry, MultidisciplinaryCOIL BLOCK-COPOLYMERSCYLINDRICAL COPOLYPEPTIDE BRUSHESHIGH-MOLECULAR-WEIGHTMESENCHYMAL STEM-CELLSNONVIRAL GENE DELIVERYPHOSGENE-FREE SYNTHESISPhysical SciencesScience & TechnologySTAR-SHAPED POLYPEPTIDESTEMPERATURE-SENSITIVE POLYPEPTIDETRIGGERED CARGO RELEASE
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