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Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

journal contribution
posted on 2012-01-01, 00:00 authored by Natalie Debeljuh, S Varghese, Colin BarrowColin Barrow, Nolene ByrneNolene Byrne
We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

History

Journal

Australian journal of chemistry

Volume

65

Issue

11

Pagination

1502 - 1506

Publisher

CSIRO Publishing

Location

Melbourne, Vic.

ISSN

0004-9425

eISSN

1445-0038

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2012, CSIRO