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Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids
journal contribution
posted on 2012-01-01, 00:00 authored by Natalie Debeljuh, S Varghese, Colin BarrowColin Barrow, Nolene ByrneNolene ByrneWe report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.
History
Journal
Australian journal of chemistryVolume
65Issue
11Pagination
1502 - 1506Publisher
CSIRO PublishingLocation
Melbourne, Vic.Publisher DOI
ISSN
0004-9425eISSN
1445-0038Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2012, CSIROUsage metrics
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