mcnaughton-roleofdietary-2005.pdf (611.47 kB)
Role of dietary factors in the development of basal cell cancer and squamous cell cancer of the skin
journal contribution
posted on 2005-07-01, 00:00 authored by Sarah McNaughtonSarah McNaughton, G Marks, A GreenThe role of dietary factors in the development of skin cancer has been investigated for many years; however, the results of epidemiologic studies have not been systematically reviewed. This article reviews human studies of basal cell cancer (BCC) and squamous cell cancer (SCC) and includes all studies identified in the published scientific literature investigating dietary exposure to fats, retinol, carotenoids, vitamin E, vitamin C, and selenium. A total of 26 studies were critically reviewed according to study design and quality of the epidemiologic evidence. Overall, the evidence suggests a positive relationship between fat intake and BCC and SCC, an inconsistent association for retinol, and little relation between ß-carotene and BCC or SCC development. There is insufficient evidence on which to make a judgment about an association of other carotenoids with skin cancer. The evidence for associations between vitamin E, vitamin C, and selenium and both BCC and SCC is weak. Many of the existing studies contain limitations, however, and further well-designed and implemented studies are required to clarify the role of diet in skin cancer. Additionally, the role of other dietary factors, such as flavonoids and other polyphenols, which have been implicated in skin cancer development in animal models, needs to be investigated.
History
Journal
Cancer epidemiology biomarkers & preventionVolume
14Issue
7Pagination
1596 - 1607Publisher
American Association for Cancer ResearchLocation
Philadelphia, PaPublisher DOI
Link to full text
ISSN
1055-9965eISSN
1538-7755Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2005, American Association for Cancer ResearchUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC