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Role of nitric oxide in skeletal muscle glucose uptake during exercise
journal contribution
posted on 2014-12-01, 00:00 authored by Y H Hong, Andrew BetikAndrew Betik, G K McConellNitric oxide is produced within skeletal muscle fibres and has various functions in skeletal muscle. There is evidence that NO may be essential for normal increases in skeletal muscle glucose uptake during contraction/exercise. Although there have been some discrepant results, it has been consistently demonstrated that inhibition of NO synthase (NOS) attenuates the increase in skeletal muscle glucose uptake during contraction in mouse and rat muscle ex vivo, during in situ contraction in rats and during exercise in humans. The NO-mediated increase in skeletal muscle glucose uptake during contraction/exercise is probably due to the modulation of intramuscular signalling that ultimately increases glucose transporter 4 (GLUT4) translocation and is, surprisingly, independent of blood flow. In this review, we discuss the evidence for and against a role of NO in regulating skeletal muscle glucose uptake during contraction/exercise and outline the possible mechanism(s) involved. Emerging findings regarding the role of neuronal NOS mu (nNOSμ) in this process are also discussed.
History
Journal
Experimental physiologyVolume
99Issue
12Pagination
1569 - 1573Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
ISSN
0958-0670eISSN
1469-445XLanguage
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
Keywords
AnimalsBiological TransportExerciseGlucoseHumansMiceMuscle ContractionMuscle, SkeletalNitric OxidePhysical Conditioning, AnimalRatsScience & TechnologyLife Sciences & BiomedicinePhysiologyLIFE-STYLE INTERVENTIONSYNTHASE INHIBITIONBLOOD-FLOWPROTEIN-KINASECGMP FORMATIONIN-VIVOCONTRACTIONTRANSPORTINSULINPhysiology
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