SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study
journal contributionposted on 2014-01-01, 00:00 authored by M R Pizzo de Castro, M Maes, R L Guembarovski, C B Ariza, E M Reiche, H O Vargas, M M Vargas, L G de Melo, Seetal DoddSeetal Dodd, Michael BerkMichael Berk, M A Watanabe, S O Nunes
The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current tobacco use disorder, diagnosed according to DSM IV criteria (n = 185), and never-smokers, diagnosed according to CDC criteria (n = 175), were recruited and received 52 weeks of combined pharmacotherapy and cognitive therapy. Successful smoking cessation was defined as exhaled carbon monoxide < 6 ppm. SLC6A4 gene STin2 VNTR polymorphism was assessed using a Multiplex-PCR-based method. At baseline, participants were evaluated using the Fagerström Test for Nicotine Dependence (FTND) and the ASSIST scale.
Pagination1 - 9
Publication classificationC1 Refereed article in a scholarly journal; C Journal article
Copyright notice2014, Biomed Central
Read the peer-reviewed publication
PolymorphismSmoking CessationTobacco Use DisorderGeneticSTin2 VNTRSerotoninInflammationOxidative stressScience & TechnologyLife Sciences & BiomedicineGenetics & HereditySEROTONIN TRANSPORTER GENENICOTINE-DEPENDENCECLINICAL CHARACTERISTICSINFLAMMATORY MARKERSCIGARETTE-SMOKING5-HTTLPRBEHAVIORRECEPTORAVAILABILITY