ward-socsproteinsinimmunity-2021.pdf (1.7 MB)
Download fileSOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer
journal contribution
posted on 2021-09-01, 00:00 authored by Mohamed SobahMohamed Sobah, Clifford LiongueClifford Liongue, Alister WardAlister WardCytokine signaling represents one of the cornerstones of the immune system, mediating the complex responses required to facilitate appropriate immune cell development and function that supports robust immunity. It is crucial that these signals be tightly regulated, with dysregulation underpinning immune defects, including excessive inflammation, as well as contributing to various immune-related malignancies. A specialized family of proteins called suppressors of cytokine signaling (SOCS) participate in negative feedback regulation of cytokine signaling, ensuring it is appropriately restrained. The eight SOCS proteins identified regulate cytokine and other signaling pathways in unique ways. SOCS1–3 and CISH are most closely involved in the regulation of immune-related signaling, influencing processes such polarization of lymphocytes and the activation of myeloid cells by controlling signaling downstream of essential cytokines such as IL-4, IL-6, and IFN-γ. SOCS protein perturbation disrupts these processes resulting in the development of inflammatory and autoimmune conditions as well as malignancies. As a consequence, SOCS proteins are garnering increased interest as a unique avenue to treat these disorders
History
Journal
Frontiers in MedicineVolume
8Article number
727987Pagination
1 - 23Publisher
FrontiersLocation
Lausanne, SwitzerlandPublisher DOI
Link to full text
ISSN
2296-858XeISSN
2296-858XLanguage
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Categories
Keywords
cancerCHRONIC MYELOID-LEUKEMIAcytokineCYTOKINE SIGNALING 3DENDRITIC CELLSGeneral & Internal MedicineIFN-GAMMAimmunityINDUCIBLE SH2-CONTAINING PROTEINinflammationLife Sciences & BiomedicineMedicine, General & InternalMESSENGER-RNAMICE LACKING SUPPRESSORPHYSIOLOGICAL NEGATIVE REGULATORREGULATORY T-CELLSScience & TechnologySH2 DOMAINSOCS