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Sarcopenia and the common mental disorders: a potential regulatory role of skeletal muscle on brain function?
journal contributionposted on 01.10.2015, 00:00 authored by Julie PascoJulie Pasco, Lana WilliamsLana Williams, Felice JackaFelice Jacka, Nicole Stupka, Sharon Brennan-OlsenSharon Brennan-Olsen, Kara KewKara Kew, Michael BerkMichael Berk
While it is understood that body composition impacts on physical conditions, such as diabetes and cardiovascular disease, it is only now apparent that body composition might play a role in the genesis of common mental disorders, depression and anxiety. Sarcopenia occurs in ageing and comprises a progressive decline in muscle mass, strength and function, leading to frailty, decreased independence and poorer quality of life. This review presents an emerging body of evidence to support the hypothesis that shared pathophysiological pathways for sarcopenia and the common mental disorders constitute links between skeletal muscle and brain function. Contracting skeletal muscle secretes neurotrophic factors that are known to play a role in mood and anxiety, and have the dual role of nourishing neuronal growth and differentiation, while protecting the size and number of motor units in skeletal muscle. Furthermore, skeletal muscle activity has important immune and redox effects that impact behaviour and reduce muscle catabolism.