szymlekgay-seleniumstatus-2018.pdf (661.83 kB)
Download fileSelenium status is not associated with cognitive performance: a cross-sectional study in 154 older Australian adults
journal contribution
posted on 2018-12-01, 00:00 authored by Barbara R Cardoso, Ewa Szymlek-GayEwa Szymlek-Gay, Blaine R Roberts, Melissa Formica, Jenny GianoudisJenny Gianoudis, Stella O'ConnellStella O'Connell, Caryl NowsonCaryl Nowson, Robin DalyRobin DalySelenium was suggested to play a role in modulating cognitive performance and dementia risk. Thus, this study aimed to investigate the association between selenium status and cognitive performance, as well as inflammatory and neurotrophic markers in healthy older adults. This cross-sectional study included 154 older adults (≥60 years) from Victoria, Australia. Participants were assessed for cognitive performance (Cogstate battery), dietary selenium intake (two 24-h food recalls), plasma selenium concentration, inflammatory markers (interleukin (IL)-6, -8, -10, tumor necrosis factor-alpha and adiponectin) and neurotrophic factors (brain-derived neurotrophic factor, vascular endothelial growth factor and insulin-like growth factor 1). Dietary selenium intake was adequate for 85% of all participants. The prevalence of selenium deficiency was low; only 8.4% did not have the minimum concentration in plasma required for optimization of iodothyronine 5' deiodinases activity. Multiple linear regression analysis revealed that plasma selenium was not associated with cognitive performance, inflammatory markers nor neurotrophic factors, independent of age, sex, body mass index (BMI), habitual physical activity, APOE status, education, and history of cardiovascular disease. The lack of association might be due to the optimization of selenoproteins synthesis as a result of adequate selenium intake. Future prospective studies are recommended to explore potential associations of selenium status with age-associated cognitive decline.
History
Journal
NutrientsVolume
10Issue
12Article number
1847Pagination
1 - 12Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
Link to full text
eISSN
2072-6643Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, the authorsUsage metrics
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Categories
Keywords
seleniumcognitiondementiainflammatory markersneurotrophic factorsBrain-Derived Neurotrophic FactorCognitive DysfunctionCytokinesInflammationNutritional StatusScience & TechnologyLife Sciences & BiomedicineNutrition & DieteticsCOGSTATE BRIEF BATTERYHUMAN SELENOPROTEIN HALZHEIMERS-DISEASEOXIDATIVE STRESSMITOCHONDRIAL BIOGENESISDEFICIENCY INCREASESPLASMA SELENIUMKAPPA-BBRAIN