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Selenium status is not associated with cognitive performance: A cross-sectional study in 154 older Australian adults

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Version 2 2024-06-06, 09:30
Version 1 2019-01-31, 10:59
journal contribution
posted on 2024-06-06, 09:30 authored by BR Cardoso, Ewa Szymlek-GayEwa Szymlek-Gay, BR Roberts, M Formica, Jenny GianoudisJenny Gianoudis, S O’connell, Caryl NowsonCaryl Nowson, Robin DalyRobin Daly
Selenium was suggested to play a role in modulating cognitive performance and dementia risk. Thus, this study aimed to investigate the association between selenium status and cognitive performance, as well as inflammatory and neurotrophic markers in healthy older adults. This cross-sectional study included 154 older adults (≥60 years) from Victoria, Australia. Participants were assessed for cognitive performance (Cogstate battery), dietary selenium intake (two 24-h food recalls), plasma selenium concentration, inflammatory markers (interleukin (IL)-6, -8, -10, tumor necrosis factor-alpha and adiponectin) and neurotrophic factors (brain-derived neurotrophic factor, vascular endothelial growth factor and insulin-like growth factor 1). Dietary selenium intake was adequate for 85% of all participants. The prevalence of selenium deficiency was low; only 8.4% did not have the minimum concentration in plasma required for optimization of iodothyronine 5′ deiodinases activity. Multiple linear regression analysis revealed that plasma selenium was not associated with cognitive performance, inflammatory markers nor neurotrophic factors, independent of age, sex, body mass index (BMI), habitual physical activity, APOE status, education, and history of cardiovascular disease. The lack of association might be due to the optimization of selenoproteins synthesis as a result of adequate selenium intake. Future prospective studies are recommended to explore potential associations of selenium status with age-associated cognitive decline.

History

Journal

Nutrients

Volume

10

Article number

ARTN 1847

Pagination

1 - 12

Location

Switzerland

ISSN

2072-6643

eISSN

2072-6643

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, the authors

Issue

12

Publisher

MDPI