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Sequence comparison of the non-structural genes of four different types of Aleutian mink disease parvovirus indicates an unusual degree of variability

Version 2 2024-06-04, 06:32
Version 1 2017-05-17, 14:21
journal contribution
posted on 2024-06-04, 06:32 authored by E Gottschalck, Soren AlexandersenSoren Alexandersen, T Storgaard, ME Bloom, B Aasted
The present work shows that at least four different sequence types of Aleutian mink disease parvovirus (ADV) are present in ADV isolates from mink. We here report the nucleotide sequences of these four types of ADV from nucleotide 123 to 2208 (map unit 3 to 46). This part of the genome encodes three non-structural (NS) proteins of ADV. Comparison of the deduced amino acid sequences of these NS proteins showed that the ADV proteins are much less conserved than the NS proteins from other members of the autonomous group of parvoviruses. In general, we found that the middle region of the ADV NS-1 protein was relatively well conserved among the types, while both the amino- and carboxy-terminal ends of the protein had higher amino acid variability. Interestingly, the putative NS-3 protein from type 3 ADV is truncated in the carboxy-terminal end. The molecular evolutionary relationship among the four types of ADV was examined. This analysis, taken together with the unusually high degree of variability of the ADV types, indicates that the ADV infection in mink is likely to be an old infection compared to the other parvovirus infections or, alternatively, that ADV accumulates sequence changes much faster than other parvoviruses.

History

Journal

Archives of Virology

Volume

138

Pagination

213-231

Location

Wien, Austria

ISSN

0304-8608

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1994, Springer-Verlag

Issue

3-4

Publisher

Springer Wien