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Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet
journal contributionposted on 2008-08-01, 00:00 authored by L Guimarães, Felice JackaFelice Jacka, C Gama, Michael BerkMichael Berk, C Leitão-Azevedo, M Belmonte de Abreu, M Lobato, A Andreazza, K Ceresér, F Kapczinski, P Belmonte-de-Abreu
Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (p = 0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.
JournalProgress in neuro-psychopharmacology & biological psychiatry
Pagination1595 - 1598
LocationAmsterdam, The Netherlands
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice2008, Elsevier Inc.
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BDNFBMIhypocaloric dietneurotrophinsschizophreniaScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesPharmacology & PharmacyPsychiatryNeurosciences & NeurologyACID REACTIVE SUBSTANCESLONG-TERM TREATMENTOXIDATIVE STRESSBIPOLAR DISORDEROPCRIT DIAGNOSESDECREASED LEVELSBDNF LEVELSFAT DIETRESTRICTIONPLASTICITY