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Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
journal contribution
posted on 2023-02-20, 00:45 authored by AS Noman, M Uddin, AA Chowdhury, MJ Nayeem, Z Raihan, MI Rashid, AK Azad, ML Rahman, D Barua, A Sultana, A Shirin, J Ferdous, RR Parag, SM Rahman, MR Mahmud, CS Jerin, N Jahan, A Siddiqua, T Ara, EB Sabur, SS Alam, S Baidya, S Akther, MZ Rahman, T Banu, AK Murugan, S Sabri, Shariful IslamShariful Islam, B Karakas, A Aboussekhra, H Yeger, WA Farhat, SS IslamAbstractSerum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked immunoassays. All patients were regularly monitored for event free survival (EFS) and overall survival (OS). Overall outcome analysis was based on serum Shh and IL-6 levels. In patients with progressive metastatic BC, both serum Shh and IL-6 concentrations were elevated in 44% (29 of 65) and 63% (41 of 65) of patients, respectively, at a statistically significant level [Shh (p = 0.0001) and IL-6 (p = 0.0001)] compared to the low levels in healthy volunteers. Serum levels tended to increase with metastatic progression and lymph node positivity. High serum Shh and IL-6 levels were associated with poor EFS and OS opposite to the negative or lower levels in serum Shh and IL-6. The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recurrence and bone metastasis, and associated with a worse survival for patients with progressive metastatic BC. Further studies are warranted for validating these biomarkers as prognostic tools in a larger patient cohort and in a longer follow-up study.
History
Journal
SCIENTIFIC REPORTSVolume
7Article number
ARTN 1796Location
EnglandPublisher DOI
ISSN
2045-2322eISSN
2045-2322Language
EnglishPublication classification
C1.1 Refereed article in a scholarly journalIssue
1Publisher
NATURE PUBLISHING GROUPUsage metrics
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No categories selectedKeywords
Science & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsSTEM-CELLSMESENCHYMAL TRANSITIONTHERAPEUTIC TARGETSIGNALING PATHWAYTUMOR-GROWTHSURVIVALPREDICTANGIOGENESISRESISTANCECYTOKINESBiomarkers, TumorBone NeoplasmsBreast NeoplasmsCase-Control StudiesDisease ProgressionFemaleHedgehog ProteinsHumansInterleukin-6Neoplasm MetastasisNeoplasm StagingPrognosisROC CurveWhole Body ImagingPreventionCancerClinical ResearchBreast Cancer4 Detection, screening and diagnosis2 Aetiology4.2 Evaluation of markers and technologies2.1 Biological and endogenous factors
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