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Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

journal contribution
posted on 2023-02-08, 03:38 authored by AL Teixeira, LB Martins, Michael BerkMichael Berk, ME Bauer
Abstract Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.

History

Journal

Clinical Science

Volume

136

Pagination

1257-1280

Location

London, Eng.

ISSN

0143-5221

eISSN

1470-8736

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

17

Publisher

Portland Press