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Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities
journal contribution
posted on 2023-02-08, 03:38 authored by AL Teixeira, LB Martins, Michael BerkMichael Berk, ME BauerAbstract
Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.
History
Journal
Clinical ScienceVolume
136Pagination
1257-1280Location
London, Eng.Publisher DOI
ISSN
0143-5221eISSN
1470-8736Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
17Publisher
Portland PressUsage metrics
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No categories selectedKeywords
AUTOIMMUNE-DISEASESBIPOLAR DISORDERINDUCED WEIGHT-GAINLife Sciences & BiomedicineMAJOR DEPRESSIVE DISORDERMedicine, Research & ExperimentalMETABOLIC SYNDROMEMITOCHONDRIAL DYSFUNCTIONMULTIPLE-SCLEROSISPSYCHOSOCIAL STRESSResearch & Experimental MedicineScience & TechnologyT-CELLSTHYROID AUTOIMMUNITYMental disorderMood disorderSchizophreniacardiovascular diseaseinflammationmetabolic disordersComorbidityHumansInflammationMental DisordersMood DisordersCardiovascularBrain DisordersMental HealthSerious Mental IllnessPreventionPatient SafetyHeart DiseaseObesity2 Aetiology2.1 Biological and endogenous factorsMental health3 Good Health and Well BeingMedical and Health Sciences
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