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Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1
journal contribution
posted on 2023-02-09, 22:41 authored by A K Chisholm, F Lami, K M Haebich, A Ure, A Brignell, T Maloof, N A Pride, K S Walsh, A Maier, M Rouel, Y Granader, B Barton, H Darke, Ian FuelscherIan Fuelscher, G Dabscheck, V A Anderson, K Williams, K N North, Jonathan M. PayneThis study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3–16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.