turner-sexfatand-2001.pdf (1.6 MB)
Sex, fat and the tilt of the earth: effects of sex and season on the feeding response to centrally administered leptin in sheep
journal contribution
posted on 2001-06-01, 00:00 authored by I J Clarke, A J Tilbrook, Anne TurnerAnne Turner, B W Doughton, J W GodingWhilst there have been many studies in various species examining the effects of leptin on food intake, there is a paucity of data comparing responsiveness in the two sexes. We have, therefore, addressed this issue in sheep. Because this species shows seasonal variation in voluntary food intake (VFI), we also considered the possibility that there might be seasonal variation in the responsivity to leptin. Centrally administered leptin was relatively ineffective as a satiety factor in either sex during AUTUMN: In Spring, leptin had a profound inhibitory effect on VFI in the females, but only a slight effect in males. These data indicate that responsiveness to leptin depends on sex and also on season in animals that are substantially affected by photoperiod.
History
Journal
EndocrinologyVolume
142Issue
6Pagination
2725 - 2728Publisher
Endocrine SocietyLocation
Bethesda, Md.Publisher DOI
ISSN
0013-7227Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2001, Endocrine SocietyUsage metrics
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