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Short-term QT interval variability in patients with coronary artery disease and congestive heart failure: a comparison with healthy control subjects

Version 2 2024-06-06, 03:01
Version 1 2020-01-02, 12:56
journal contribution
posted on 2024-06-06, 03:01 authored by Y Li, P Li, X Wang, Chandan KarmakarChandan Karmakar, C Liu
This study aimed to test how different QT interval variability (QTV) indices change in patients with coronary artery disease (CAD) and congestive heart failure (CHF). Twenty-nine healthy volunteers, 29 age-matched CAD patients, and 20 age-matched CHF patients were studied. QT time series were derived from 5-min resting lead-II electrocardiogram (ECG). Time domain indices [mean, SD, and QT variability index (QTVI)], frequency-domain indices (LF and HF), and nonlinear indices [sample entropy (SampEn), permutation entropy (PE), and dynamical patterns] were calculated. In order to account for possible influence of heart rate (HR) on QTV, all the calculations except QTVI were repeated on HR-corrected QT time series (QTc) using three correction methods (i.e., Bazett, Fridericia, and Framingham method). Results showed that CHF patients exhibited increased mean, increased SD, increased LF and HF, decreased T-wave amplitude, increased QTVI, and decreased PE, while showed no significant changes in SampEn. Interestingly, CHF patients also showed significantly changed distribution of the dynamical patterns with less monotonously changing patterns while more fluctuated patterns. In CAD group, only QTVI was found significantly increased as compared with healthy controls. Results after HR correction were in common with those before HR correction except for QTc based on Bazett correction.

History

Journal

Medical and Biological Engineering and Computing

Volume

57

Pagination

389-400

Location

United States

ISSN

0140-0118

eISSN

1741-0444

Language

English

Notes

In press

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, International Federation for Medical and Biological Engineering

Issue

2

Publisher

SPRINGER HEIDELBERG