File(s) under permanent embargo

Short communication: sex-linked differences in gamma-aminobutyric acid (GABA) are related to social functioning in autism spectrum disorder

journal contribution
posted on 30.04.2018, 00:00 authored by Melissa KirkovskiMelissa Kirkovski, Chao Suo, Peter EnticottPeter Enticott, Murat Yücel, Paul Bernard Fitzgerald
Magnetic resonance spectroscopy (MRS) was utilized to investigate sex differences in gamma-aminobutyric acid (GABA) between adults with autism spectrum disorder (ASD) and neurotypical (NT) controls. GABA at the right superior temporal sulcus (STS) is reported for 12 ASD and 14 NT participants. The results show no group differences in GABA. There was, however, a significant positive association between GABA at the STS and autism-related social impairments in females with ASD. These findings provide preliminary support for sex differences in GABAergic distribution and processes that contribute to social functioning in ASD.

History

Journal

Psychiatry research: neuroimaging

Volume

274

Pagination

19 - 22

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0925-4927

eISSN

1872-7506

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, Elsevier B.V.