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Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

Version 2 2024-06-20, 00:11
Version 1 2024-03-28, 04:36
journal contribution
posted on 2024-06-20, 00:11 authored by S Telwatte, AC Hearps, A Johnson, CF Latham, K Moore, Paul AgiusPaul Agius, M Tachedjian, S Sonza, N Sluis-Cremer, PR Harrigan, G Tachedjian
Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

History

Journal

Nucleic Acids Research

Volume

43

Pagination

3256-3271

Location

England

Publisher DOI

ISSN

0305-1048

eISSN

1362-4962

Language

en

Author URL

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

6

Publisher

Oxford University Press (OUP)

Publication URL

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    Research Publications

    Categories

    Keywords

    Anti-HIV AgentsBase SequenceCell LineCodonDrug Resistance, ViralHEK293 CellsHIV InfectionsHIV Reverse TranscriptaseHIV-1HumansINDEL MutationMutationRNA, ViralReverse Transcriptase Inhibitors

    Licence

    CC BY 4.0

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