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Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization
journal contribution
posted on 2010-06-30, 00:00 authored by Puwang Li, Yichao Wang, Zheng Peng, Lingxue KongLingxue KongA combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.
History
Journal
Materials science forumVolume
654-656Pagination
2265 - 2268Publisher
Trans Tech PublicationsLocation
Stafa-Zurich, SwitzerlandISSN
0255-5476Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2010, Trans Tech PublicationsUsage metrics
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