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Site of action of hypertonic saline in the canine lung

Version 2 2024-06-13, 15:18
Version 1 2022-03-23, 09:06
journal contribution
posted on 2024-06-13, 15:18 authored by PD Sly, CJ Lanteri
The site of action of inhaled hypertonic saline was determined in 8- to 10-wk-old puppies by combining measurements of respiratory mechanics, made during mechanical ventilation and after midexpiratory flow interruptions, with direct measurements of alveolar pressure. Under both control conditions and after inhalation of 10% saline, we were able to partition lung mechanics into components representing the airways and tissue viscoelastic properties. Hypertonic saline challenge altered lung mechanics by increasing airway resistance and did not have any effect on elastic or viscoelastic properties of the lung.

History

Journal

Journal of Applied Physiology

Volume

71

Pagination

1315-1321

Location

United States

ISSN

0161-7567

eISSN

1522-1601

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

4

Publisher

AMER PHYSIOLOGICAL SOC