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Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

journal contribution
posted on 2024-08-20, 06:05 authored by CE Winbanks, Kate Murphy, BC Bernardo, H Qian, Y Liu, PV Sepulveda, C Beyer, A Hagg, RE Thomson, JL Chen, KL Walton, KL Loveland, JR McMullen, BD Rodgers, CA Harrison, GS Lynch, P Gregorevic
Muscle-directed Smad7 gene delivery prevents the loss of skeletal muscle mass and strength in mouse models of cachexia, an important contributor to poor prognosis in patients with advanced cancer.

History

Journal

Science Translational Medicine

Volume

8

Article number

ARTN 348ra98

Pagination

348ra98-

Location

United States

Publisher DOI

ISSN

1946-6234

eISSN

1946-6242

Language

eng

Author URL

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

348

Publisher

American Association for the Advancement of Science (AAAS)

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    Research Publications

    Categories

    Keywords

    Activin Receptors, Type IIAnimalsBlotting, WesternMiceMuscle ProteinsMuscle, SkeletalMuscular AtrophyMyocardiumNeoplasmsPhosphorylationSKP Cullin F-Box Protein LigasesSignal TransductionSmad2 ProteinSmad3 ProteinSmad7 ProteinTripartite Motif ProteinsUbiquitin-Protein Ligases

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    All Rights Reserved

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