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Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

journal contribution
posted on 2024-08-20, 06:05 authored by CE Winbanks, Kate Murphy, BC Bernardo, H Qian, Y Liu, PV Sepulveda, C Beyer, A Hagg, RE Thomson, JL Chen, KL Walton, KL Loveland, JR McMullen, BD Rodgers, CA Harrison, GS Lynch, P Gregorevic
Muscle-directed Smad7 gene delivery prevents the loss of skeletal muscle mass and strength in mouse models of cachexia, an important contributor to poor prognosis in patients with advanced cancer.

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  1. 1.
    DOI - Is version of https://doi.org/10.1126/scitranslmed.aac4976

Location

United States

Language

eng

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Publication classification

C1.1 Refereed article in a scholarly journal

Journal

Science Translational Medicine

Volume

8

Article number

ARTN 348ra98

Pagination

348ra98-

ISSN

1946-6234

eISSN

1946-6242

Issue

348

Publisher

American Association for the Advancement of Science (AAAS)

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    Research Publications

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    Keywords

    Activin Receptors, Type IIAnimalsBlotting, WesternMiceMuscle ProteinsMuscle, SkeletalMuscular AtrophyMyocardiumNeoplasmsPhosphorylationSKP Cullin F-Box Protein LigasesSignal TransductionSmad2 ProteinSmad3 ProteinSmad7 ProteinTripartite Motif ProteinsUbiquitin-Protein Ligases

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