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Social dysfunction after pediatric traumatic brain injury: a translational perspective
journal contribution
posted on 2016-05-01, 00:00 authored by Nicholas RyanNicholas Ryan, Cathy Catroppa, Celia Godfrey, Linda J Noble-Haeusslein, Sandy R Shultz, Terence J O'Brien, Vicki Anderson, Bridgette D SempleSocial dysfunction is common after traumatic brain injury (TBI), contributing to reduced quality of life for survivors. Factors which influence the development or persistence of social deficits after injury remain poorly understood, particularly in the context of ongoing brain maturation during childhood and adolescence. Aberrant social interactions have recently been modeled in adult and juvenile rodents after experimental TBI, providing an opportunity to gain new insights into the underlying neurobiology of these behaviors. Here, we review our current understanding of social dysfunction in both humans and rodent models of TBI, with a focus on brain injuries acquired during early development. Modulators of social outcomes are discussed, including injury-related and environmental risk and resilience factors. Disruption of social brain network connectivity and aberrant neuroendocrine function are identified as potential mechanisms of social impairments after pediatric TBI. Throughout, we highlight the overlap and disparities between outcome measures and findings from clinical and experimental approaches, and explore the translational potential of future research to prevent or ameliorate social dysfunction after childhood TBI.
History
Journal
Neuroscience & biobehavioral reviewsVolume
64Pagination
196 - 214Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0149-7634eISSN
1873-7528Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2016, ElsevierUsage metrics
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BehaviorBrainChildrenCommunicationHumansPediatricRodentsSocial brain networkSocial competencySocial interactionsTraumatic brain injuryAnimalsBrain Injuries, TraumaticChildSocial BehaviorScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyBEHAVIORAL TASKS RELEVANTSCENT MARKING BEHAVIORPROBLEM-SOLVING SKILLSCLOSED-HEAD-INJURYRECOVERY 10 YEARSULTRASONIC VOCALIZATIONSENVIRONMENTAL ENRICHMENTPSYCHOSOCIAL OUTCOMESCOGNITIVE FUNCTIONMOUSE MODEL
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