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Sometimes it's good to be short: the serotonin transporter gene, positive parenting, and adolescent depression

journal contribution
posted on 01.07.2019, 00:00 authored by Keri LittleKeri Little, Craig OlssonCraig Olsson, S Whittle, Jacqui MacdonaldJacqui Macdonald, L B Sheeber, George Youssef, J G Simmons, A V Sanson, D L Foley, N B Allen
In threatening environments, the short (S) allele of 5-HTTLPR is proposed to augment risk for depression. However, it is unknown whether 5-HTTLPR variation increases risk for depression in environments of deprivation, lacking positive or nurturant features. Two independent longitudinal studies (n = 681 and 176, respectively) examined whether 5-HTTLPR moderated associations between low levels of positive parenting at 11-13 years and subsequent depression at 17-19 years. In both studies only LL homozygous adolescents were at greater risk for depression with decreasing levels of positive parenting. Thus, while the S allele has previously been identified as a susceptible genotype, these findings suggest that the L allele may also confer sensitivity to depression in the face of specific environmental challenges.

History

Journal

Child development

Volume

90

Issue

4

Season

July/August

Pagination

1061 - 1079

Publisher

John Wiley & Sons

Location

Chichester, Eng.

eISSN

1467-8624

Language

eng

Publication classification

C1 Refereed article in a scholarly journal; C Journal article

Copyright notice

2017, The Authors