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Spatio-temporal source cluster analysis reveals fronto-temporal auditory change processing differences within a shared autistic and schizotypal trait phenotype

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Version 2 2024-06-05, 03:38
Version 1 2019-06-20, 17:00
journal contribution
posted on 2024-06-18, 15:30 authored by Talitha FordTalitha Ford, W Woods, DP Crewther
Social Disorganisation (SD) is a shared autistic and schizotypal phenotype that is present in the subclinical population. Auditory processing deficits, particularly in mismatch negativity/field (MMN/F) have been reported across both spectrum disorders. This study investigates differences in MMN/F cortical spatio-temporal source activity between higher and lower quintiles of the SD spectrum. Sixteen low (9 female) and 19 high (9 female) SD subclinical adults (18-40years) underwent magnetoencephalography (MEG) during an MMF paradigm where standard tones (50ms) were interrupted by infrequent duration deviants (100ms). Spatio-temporal source cluster analysis with permutation testing revealed no difference between the groups in source activation to the standard tone. To the deviant tone however, there was significantly reduced right hemisphere fronto-temporal and insular cortex activation for the high SD group (p= 0.038). The MMF, as a product of the cortical response to the deviant minus that to the standard, did not differ significantly between the high and low Social Disorganisation groups. These data demonstrate a deficit in right fronto-temporal processing of an auditory change for those with more of the shared SD phenotype, indicating that right fronto-temporal auditory processing may be associated with psychosocial functioning.

History

Journal

NeuroImage: Clinical

Volume

16

Pagination

383-389

Location

Netherlands

Open access

  • Yes

ISSN

2213-1582

eISSN

2213-1582

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2017, The Authors

Publisher

ELSEVIER SCI LTD