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Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes

journal contribution
posted on 1994-04-01, 00:00 authored by Colin BarrowColin Barrow, H H Sun
A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperazines.

History

Journal

Journal of natural products

Volume

57

Issue

4

Pagination

471 - 476

Publisher

American Chemical Society

Location

Washington, D.C.

ISSN

0163-3864

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

[1994, American Chemical Society]