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Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes
journal contributionposted on 1994-04-01, 00:00 authored by Colin BarrowColin Barrow, H H Sun
A novel substance P inhibitor, spiroquinazoline , was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione , and the known compounds, acyl aszonalenin , N-benzoyl-L-phenylalaninol, and seven diketopiperazines.