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Spontaneously occurring tumors in different wild-derived strains of hydra

Version 3 2024-06-19, 19:01
Version 2 2024-06-02, 22:36
Version 1 2023-05-26, 04:33
journal contribution
posted on 2024-06-19, 19:01 authored by J Boutry, M Buysse, S Tissot, C Cazevielle, R Hamede, Antoine DujonAntoine Dujon, Beata UjvariBeata Ujvari, M Giraudeau, A Klimovich, F Thomas, J Tökölyi
AbstractHydras are freshwater cnidarians widely used as a biological model to study different questions such as senescence or phenotypic plasticity but also tumoral development. The spontaneous tumors found in these organisms have been so far described in two female lab strains domesticated years ago (Hydra oligactis and Pelmatohydra robusta) and the extent to which these tumors can be representative of tumors within the diversity of wild hydras is completely unknown. In this study, we examined individuals isolated from recently sampled wild strains of different sex and geographical origin, which have developed outgrowths looking like tumors. These tumefactions have common features with the tumors previously described in lab strains: are composed of an accumulation of abnormal cells, resulting in a similar enlargement of the tissue layers. However, we also found diversity within these new types of tumors. Indeed, not only females, but also males seem prone to form these tumors. Finally, the microbiota associated to these tumors is different from the one involved in the previous lineages exhibiting tumors. We found that tumorous individuals hosted yet undescribed Chlamydiales vacuoles. This study brings new insights into the understanding of tumor susceptibility and diversity in brown hydras from different origins.

History

Journal

Scientific reports

Volume

13

Article number

7449

Pagination

1-11

Location

Berlin, Germany

ISSN

2045-2322

eISSN

2045-2322

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

1

Publisher

Springer

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