Deakin University
athan-staphylococcusaureus-2005.pdf (159.12 kB)

Staphylococcus aureus endocarditis: a consequence of medical progress

Download (159.12 kB)
Version 2 2024-06-03, 15:32
Version 1 2016-10-17, 10:46
journal contribution
posted on 2024-06-03, 15:32 authored by VG Fowler, JM Miro, B Hoen, CH Cabell, E Abrutyn, E Rubinstein, GR Corey, D Spelman, SF Bradley, B Barsic, PA Pappas, KJ Anstrom, D Wray, CQ Fortes, I Anguera, Eugene AthanEugene Athan, P Jones, JTM van der Meer, TSJ Elliott, DP Levine, AS Bayer
CONTEXT: The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. OBJECTIVES: To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. MAIN OUTCOME MEASURE: In-hospital mortality. RESULTS: S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus IE (131 patients, 60.1%) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). CONCLUSIONS: S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.



Journal of the American Medical Association






Chocago, Ill.

Open access

  • Yes





Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2005, American Medical Association




American Medical Association