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Download fileStat5 as a diagnostic marker for leukemia
The Jak-Stat-Socs pathway is an important component of cytokine receptor signaling. Not surprisingly, perturbation of this pathway is implicated in diseases of hematopoietic and immune origin, including leukemia, lymphoma and immune deficiencies. This review examines the role of a key component of this pathway, Stat5. This has been shown to be activated in a variety of leukemias and myeloproliferative disorders, including downstream of a range of key oncogenes where it has been shown to play an important role in mediating their effects. Therefore, Stat5 represents a useful pan-leukemia/myeloproliferative disorder diagnostic marker and key therapeutic end point, as well as representing an attractive therapeutic target for these disorders.
History
Journal
Expert review of molecular diagnosticsVolume
8Issue
1Pagination
73 - 82Publisher
Expert Reviews LtdLocation
London, EnglandPublisher DOI
ISSN
1473-7159eISSN
1744-8352Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2008, Expert Reviews LtdUsage metrics
Read the peer-reviewed publication
Categories
Keywords
Molecular diagnosisScience & TechnologyLife Sciences & BiomedicinePathologycytokine signalingdiagnosticshematologyJak-Stat pathwayleukemiamyeloproliferationoncologyStat5therapeuticsCHRONIC MYELOID-LEUKEMIAABL TYROSINE KINASEACUTE LYMPHOBLASTIC-LEUKEMIARETINOIC ACID RECEPTORJAK2 V617F MUTATIONBCR-ABLCONSTITUTIVE ACTIVATIONPOLYCYTHEMIA-VERAFUSION PROTEINDNA-BINDING