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Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates

journal contribution
posted on 2003-01-01, 00:00 authored by Fred PfefferFred Pfeffer, R Russell
A versatile synthesis of amino acid and peptide functionalised [n]polynorbornane scaffolds is described. The frameworks are constructed using the stereoselective and regioselective cycloaddition of suitably functionalised chiral cyclobutene epoxides with similar norbornenes. The strategies employed allow a range of topologies to be accessed and a number of regioselectively addressable linkage points to be accommodated.

History

Journal

Organic and biomolecular chemistry

Volume

1

Pagination

1845 - 1851

Publisher

Royal Society of Chemistry

Location

Cambridge, England

ISSN

1477-0520

eISSN

1477-0539

Language

eng

Notes

First published as an Advance Article on the web 25th April 2003

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

Royal Society of Chemistry, 2003