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Strengthened Decellularized Porcine Valves via Polyvinyl Alcohol as a Template Improving Processability

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journal contribution
posted on 2024-06-18, 05:49 authored by Q Chen, C Wang, Han WangHan Wang, J Xiao, Y Zhou, S Gu, W Xu, H Yang
The heart valve is crucial for the human body, which directly affects the efficiency of blood transport and the normal functioning of all organs. Generally, decellularization is one method of tissue-engineered heart valve (TEHV), which can deteriorate the mechanical properties and eliminate allograft immunogenicity. In this study, removable polyvinyl alcohol (PVA) is used to encapsulate decellularized porcine heart valves (DHVs) as a dynamic template to improve the processability of DHVs, such as suturing. Mechanical tests show that the strength and elastic modulus of DHVs treated with different concentrations of PVA significantly improve. Without the PVA layer, the valve would shift during suture puncture and not achieve the desired suture result. The in vitro results indicate that decellularized valves treated with PVA can sustain the adhesion and growth of human umbilical vein endothelial cells (HUVECs). All results above show that the DHVs treated with water-soluble PVA have good mechanical properties and cytocompatibility to ensure post-treatment. On this basis, the improved processability of DHV treated with PVA enables a new paradigm for the manufacturing of scaffolds, making it easy to apply.

History

Journal

Polymers

Volume

16

Article number

16

Pagination

1-16

Location

Basel, Switzerland

Open access

  • Yes

ISSN

2073-4360

eISSN

2073-4360

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

1

Publisher

MDPI