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Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise

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posted on 01.04.2011, 00:00 authored by Marita Wallace, M Hock, B Hazen, A Kralli, Rod SnowRod Snow, Aaron RussellAaron Russell
Exercise improves the ability of skeletal muscle to metabolise fats and sugars. For these improvements to occur the muscle detects a signal caused by exercise, resulting in changes in genes and proteins that control metabolism. We show that endurance exercise increases the amount of a protein called striated muscle activator of Rho signalling (STARS) as well as several other proteins influenced by STARS.We also show that the amount of STARS can be increased by signals directed from proteins called peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) and oestrogen-related receptor-α (ERRα). We also observed that when we reduce the amount of STARS in muscle cells, we block the ability of PGC-1α/ERRα to increase a gene called carnitine palmitoyltransferase-1β (CPT-1β), which is important for fat metabolism. Our study has shown that the STARS pathway is regulated by endurance exercise. STARS may also play a role in fat metabolism in muscle.

History

Journal

Journal of physiology

Volume

589

Issue

8

Pagination

2027 - 2039

Publisher

Cambridge University Press

Location

London, England

ISSN

0022-3751

eISSN

1469-7793

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2011, The Physiological Society