snow-striatedmuscle-2011.pdf (659.06 kB)
Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise
journal contribution
posted on 2011-04-01, 00:00 authored by Marita Wallace, M Hock, B Hazen, A Kralli, Rod SnowRod Snow, Aaron RussellAaron RussellExercise improves the ability of skeletal muscle to metabolise fats and sugars. For these improvements to occur the muscle detects a signal caused by exercise, resulting in changes in genes and proteins that control metabolism. We show that endurance exercise increases the amount of a protein called striated muscle activator of Rho signalling (STARS) as well as several other proteins influenced by STARS.We also show that the amount of STARS can be increased by signals directed from proteins called peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) and oestrogen-related receptor-α (ERRα). We also observed that when we reduce the amount of STARS in muscle cells, we block the ability of PGC-1α/ERRα to increase a gene called carnitine palmitoyltransferase-1β (CPT-1β), which is important for fat metabolism. Our study has shown that the STARS pathway is regulated by endurance exercise. STARS may also play a role in fat metabolism in muscle.
History
Journal
Journal of physiologyVolume
589Issue
8Pagination
2027 - 2039Publisher
Cambridge University PressLocation
London, EnglandPublisher DOI
ISSN
0022-3751eISSN
1469-7793Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2011, The Physiological SocietyUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC