File(s) under permanent embargo

Structural deformation in pathogenic bacteria cells caused by marine fungal metabolites: an in vitro investigation

journal contribution
posted on 2020-09-01, 00:00 authored by Shivankar Agrawal, Colin BarrowColin Barrow, S K Deshmukh
Over the past 50 years, fungal natural products have revolutionized medicine, yielding drugs which have enormous therapeutic potential. The aim of this study was to investigate the probable effect of marine fungal natural products on various skin pathogens. Initially, seventy natural extracts obtained from 35 different marine fungal strains were analysed by the agar well diffusion and broth micro dilution assay for their antibacterial action against six human skin pathogens. The minimum inhibitory effects of all active fungal methanolic extracts on targeted pathogens were observed between 90 and 99% at the concentration of 1 mg/mL. The highest activity was recorded by fungal strains belonging to genera Penicillium, Emericellopsis and Simplicillium. Thereafter, possible effects on target bacterial cells were studied by scanning electron microscopy which show significant destruction and structural deformation in the bacterial cell wall. The results of the present study provided good evidence that the studied marine fungi can be a potential source of natural antibacterial agents against skin bacterial pathogens.

History

Journal

Microbial pathogenesis

Volume

146

Article number

104248

Pagination

1 - 13

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0882-4010

eISSN

1096-1208

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal