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Structure-activity studies of the natural product substance P antagonist win 64821
journal contribution
posted on 1995-02-16, 00:00 authored by Colin BarrowColin Barrow, L L Musza, R CooperTryptophyl alkylation at C3a of the diketopiperazine 2 gave compounds related to the substance P antagonist WIN 64821 (1). The biological activities of these compounds, and those of methyl analogs 13 and 14 produced by directed biosynthesis, gives structure-activity information for 1.