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Structure-activity studies of the natural product substance P antagonist win 64821

journal contribution
posted on 1995-02-16, 00:00 authored by Colin BarrowColin Barrow, L L Musza, R Cooper
Tryptophyl alkylation at C3a of the diketopiperazine 2 gave compounds related to the substance P antagonist WIN 64821 (1). The biological activities of these compounds, and those of methyl analogs 13 and 14 produced by directed biosynthesis, gives structure-activity information for 1.

History

Journal

Bioorganic and medicinal chemistry letters

Volume

5

Issue

4

Pagination

377 - 380

Publisher

Elsevier Science

Location

Amsterdam, The Netherlands

ISSN

0960-894X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1995, Elsevier Science