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Structure-activity studies of the natural product substance P antagonist win 64821

Version 2 2024-06-03, 13:01
Version 1 2017-07-26, 12:49
journal contribution
posted on 2024-06-03, 13:01 authored by Colin BarrowColin Barrow, LL Musza, R Cooper
Tryptophyl alkylation at C3a of the diketopiperazine 2 gave compounds related to the substance P antagonist WIN 64821 (1). The biological activities of these compounds, and those of methyl analogs 13 and 14 produced by directed biosynthesis, gives structure-activity information for 1.

History

Journal

Bioorganic and medicinal chemistry letters

Volume

5

Pagination

377-380

Location

Amsterdam, The Netherlands

Publisher DOI

ISSN

0960-894X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1995, Elsevier Science

Issue

4

Publisher

Elsevier Science

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    Research Publications

    Categories

    Keywords

    Tryptophyl alkylationC3adiketopiperazinesubstance P antagonist WIN 64821compoundsbiological activitybiosynthesis

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    All Rights Reserved

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