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Studies on the sequential development of acute interstitial pneumonia caused by Aleutian disease virus in mink kits.

journal contribution
posted on 1987-01-01, 00:00 authored by Soren AlexandersenSoren Alexandersen, M E Bloom
We studied different parameters during the development of acute interstitial pneumonia in mink kits caused by neonatal infection with Aleutian disease virus (ADV). When histological lesions, presence of intranuclear inclusion bodies, and intranuclearly localized ADV antigen were correlated with levels of single-stranded virion and duplex replicative forms of ADV DNA in the different tissues, it was concluded that the lung, probably alveolar type II cells, is the major primary target for viral replication and cytopathology. The presence of the duplex dimeric replicative-form DNA, a strong marker of parvovirus replication, was also observed in low amount in the mesenteric lymph node, suggesting replication of ADV in this organ, although no viral cytopathology could be demonstrated. Moreover, a few intranuclear inclusion bodies were demonstrated in kidney and liver from affected kits, but intranuclearly localized ADV antigen could not be demonstrated in liver sections, and neither could duplex dimer replicative-form DNA, suggesting that these organs are nevertheless not a major site of ADV replication. When the data were compared with results previously reported for ADV-infected adult mink and ADV-infected permissive cell cultures, the data suggested that the pattern of ADV replication in alveolar type II cells is similar to that seen in infected cell cultures but that the replication in the other kit organs resembles the restricted pattern seen in adult mink.

History

Journal

Journal of virology

Volume

61

Issue

1

Pagination

81 - 86

Publisher

American Society for Microbiology

Location

United States

ISSN

0022-538X

Language

eng

Publication classification

CN.1 Other journal article

Copyright notice

1987, American Society for Microbiology

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