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Study Protocol: Transitions in Adolescent Girls (TAG)

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posted on 04.02.2020, 00:00 authored by M E A Barendse, Nandi VijayakumarNandi Vijayakumar, M L Byrne, J E Flannery, T W Cheng, J C Flournoy, B W Nelson, D Cosme, A Mobasser, S J Chavez, L Hval, B Brady, H Nadel, A Helzer, E A Shirtcliff, N B Allen, J H Pfeifer
Background: Despite recent studies linking pubertal processes to brain development, as well as research demonstrating the importance of both pubertal and neurodevelopmental processes for adolescent mental health, there is limited knowledge of the full pathways and mechanisms behind the emergence of mental illnesses such as depression and anxiety disorders in adolescence. The Transitions in Adolescent Girls (TAG) study aims to understand the complex relationships between pubertal development, brain structure and connectivity, the behavioral and neural correlates of social and self-perception processes, and adolescent mental health in female adolescents.

Methods: The TAG study includes 174 female adolescents aged 10.0 to 13.0 years, recruited from the local community in Lane County, Oregon, USA. The participants, along with a parent/guardian, will complete three waves of assessment over the course of 3 years; the third wave is currently underway. Each wave includes collection of four saliva samples (one per week) and one hair sample for the assessment of hormone levels and immune factors; an MRI session including structural, diffusion, resting-state functional and task-based functional scans; the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), a diagnostic interview on current and lifetime mental health; production of a short self-narrative video; and measurement of height, weight, and waist circumference. The functional MRI tasks include a self-evaluation paradigm and a self-disclosure paradigm. In addition, adolescents and their parents/guardians complete a number of surveys to report on the adolescent's pubertal development, mental health, social environment and life events; adolescents also report on various indices of self-perception and social-emotional functioning.

Discussion: The knowledge gained from this study will include developmental trajectories of pubertal, neurological, and social processes and their roles as mechanisms in predicting emergence of mental illness in female adolescents. This knowledge will help identify modifiable, developmentally specific risk factors as targets for early intervention and prevention efforts.

History

Journal

Frontiers in Psychiatry

Volume

10

Article number

1018

Pagination

1 - 13

Publisher

Frontiers Media

Location

Lausanne, Switzerland

ISSN

1664-0640

eISSN

1664-0640

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2020, Barendse, Vijayakumar, Byrne, Flannery, Cheng, Flournoy, Nelson, Cosme, Mobasser, Chavez, Hval, Brady, Nadel, Helzer, Shirtcliff, Allen and Pfeifer