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Subfornical organ efferents influence the excitability of neurohypophyseal and tuberoinfundibular paraventricular nucleus neurons in the rat

journal contribution
posted on 1984-11-01, 00:00 authored by A V Ferguson, Trevor DayTrevor Day, L P Renaud
Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase in excitability. In 35% of cells tested, this excitation showed a long latency (44.3 +/- 3.4 ms) prolonged duration (208.7 +/- 23.5 ms), while in 16% of the neurons the excitation observed may be described as short latency (24.7 +/- 1.8 ms) short duration (11.6 +/- 1.4 ms). Of the remaining cells antidromically identified as projecting to the posterior pituitary, 12% showed initial decreases in excitability following SFO stimulation while the remaining 37% were unaffected. Evidence is presented demonstrating that stimulation in the region of the SFO results in short latency (27.9 +/- 2.4 ms) short duration (7.8 +/- 0.7 ms) increases in excitability in 22% of antidromically identified PVN tuberoinfundibular neurons tested. These data provide electrophysiological evidence in support of the proposed role of the subfornical organ in the control of posterior and anterior pituitary function.

History

Journal

Neuroendocrinology

Volume

39

Issue

5

Pagination

423 - 428

Publisher

S Karger AG

Location

Basel, Switzerland

ISSN

0028-3835

Language

eng

Publication classification

CN.1 Other journal article

Copyright notice

1984, S. Karger AG, Basel