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Subfornical organ lesion decreases sodium appetite in the sodium-depleted rat.

journal contribution
posted on 1990-08-27, 00:00 authored by R S Weisinger, D A Denton, Robert Di Nicolantonio, D K Hards, M J McKinley, B Oldfield, P G Osborne
The effect of subfornical organ (SFO) lesion on various models of ingestive behaviour was investigated in rats. Intake of water after 24 h water deprivation or systemic administration of hypertonic NaCl were not altered by SFO lesions. Intake of food or water after 24 h of food deprivation were not altered by SFO lesions. Intake of NaCl after furosemide-induced Na depletion was decreased by ablation of the SFO. This decrease in Na intake was ameliorated by pretreatment with a low dose of captopril. These results suggest that the SFO is involved in Na intake after Na depletion, but not in water or food intake following periods of water or food deprivation, respectively. The observation that a low dose of captopril can eliminate the decrease in Na appetite which occurred subsequent to SFO lesion suggests that other brain areas may also participate in Na-depletion-induced Na appetite.

History

Journal

Brain Research

Volume

526

Issue

1

Pagination

23 - 30

Publisher

Elsevier

Location

Netherlands

ISSN

1935-2875

Language

eng

Publication classification

CN.1 Other journal article

Copyright notice

1990, Elsevier