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Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia.
journal contributionposted on 1999-03-01, 00:00 authored by Michael BerkMichael Berk, H Plein, T Csizmadia
Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia. The aim of this study was to examine the platelet intracellular calcium response to glutamate using spectroflourometry in 15 schizophrenic patients and 15 matched control individuals as an index of platelet glutamate receptor sensitivity. Patients with schizophrenia had significantly lower baseline intracellular calcium levels than matched control individuals (P = 0.03). The percentage response of the schizophrenic individuals to glutamate stimulation was significantly greater than control individuals (P < 0.001). These data suggest that platelet glutamate receptors may be supersensitive in schizophrenia. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia.
JournalInternational Clinical Psychopharmacology
Pagination119 - 122
PublisherLippincott, Williams & Wilkins
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice1999, Lippincott, Williams & Wilkins
AdultBiological MarkersBlood PlateletsFemaleHumansMalePsychiatric Status Rating ScalesReceptors, GlutamateSchizophreniaSchizophrenic PsychologyScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyPsychiatryglutamateplatelet intracellular calcium responsereceptor supersensitivityD-ASPARTATE RECEPTORSINTRACELLULAR CALCIUMAFFECTIVE-DISORDERSGENERATIONSEROTONINMODEL