mathesh-supramolecular-2020.pdf (4.04 MB)
Supramolecular nanomotors with "pH taxis" for active drug delivery in the tumor microenvironment
journal contributionposted on 2020-01-01, 00:00 authored by Motilal Mathesh ShanmugamMotilal Mathesh Shanmugam, Jiawei Sun, Frans van der Sandt, Daniela A Wilson
Self-propelled nanomotors demonstrating autonomous motion in biologically relevant fuel are currently being studied to overcome the use of external physical or chemical stimuli as precise delivery agents. In this context, the tumor microenvironment (TME) with slightly acidic pH is used for developing cargo-releasing artificial systems triggered by such conditions. However, there is still a need for fabrication of smart nanomotors that can sense the acidic pH prevalent in the TME rather than using an external fuel source for selective activation and thereafter migrating towards tumors for active drug delivery. Herein, supramolecular assembly-based nanomotors are fabricated by in-situ grown CaCO3 nanoparticles and studied for their motility behaviour in endogenously generated acidic pH by HeLa cells and further exploited as an active delivery vehicle for DOX molecules to the cells for their anticancer efficacy. The nanomotors are activated in slightly acidic pH showcasing “pH taxis” towards tumor cells without the need for any sophisticated/complicated technologies or an external fuel source for active and targeted delivery of drugs.